abstract：:Macrolides such as erythromycin are the empirical treatment of Bordetella pertussis infections. China has experienced an increase in erythromycin-resistant B. pertussis isolates since they were first reported in 2013. Here, we undertook a genomic study on Chinese B. pertussis isolates from 2012 to 2015 to elucidate th...

journal_title：Emerging microbes & infections

authors： Xu Z,Wang Z,Luan Y,Li Y,Liu X,Peng X,Octavia S,Payne M,Lan R

更新日期：2019-01-01 00:00:00

abstract：:Histoplasmosis caused by the fungus Histoplasma capsulatum is often lethal in patients with AIDS. Urine antigen testing is highly sensitive and much quicker for diagnosis than culture. Histoplasmosis has a patchy and incompletely appreciated distribution around the world especially in South East Asia. We conducted a s...

journal_title：Emerging microbes & infections

authors： Baker J,Setianingrum F,Wahyuningsih R,Denning DW

更新日期：2019-01-01 00:00:00

abstract：:The isolation and characterization of monoclonal broadly neutralizing antibodies (nAbs) from natural HIV-1-infected individuals play very important roles in understanding nAb responses to HIV-1 infection and designing vaccines and therapeutics. Many broadly nAbs have been isolated from individuals infected with HIV-1 ...

journal_title：Emerging microbes & infections

authors： Ju B,Li D,Ren L,Hou J,Hao Y,Liang H,Wang S,Zhu J,Wei M,Shao Y

更新日期：2018-11-01 00:00:00

abstract：:A novel equine parvovirus, equine parvovirus-hepatitis (EqPV-H), was first discovered in a horse that died of equine serum hepatitis in the USA in 2018. EqPV-H was shown to be a novel etiological agent associated with equine serum hepatitis. Following this initial report, no additional studies on EqPV-H have been publ...

journal_title：Emerging microbes & infections

authors： Lu G,Sun L,Ou J,Xu H,Wu L,Li S

更新日期：2018-10-23 00:00:00

abstract：:Dengue virus (DENV) is a mosquito-borne Flavivirus that is endemic in many tropical and sub-tropical countries where the transmission vectors Aedes spp. mosquitoes resides. There are four serotypes of the virus. Each serotype is antigenically different, meaning they elicit heterologous antibodies. Infection with one s...

journal_title：Emerging microbes & infections

authors： Uno N,Ross TM

更新日期：2018-10-10 00:00:00

abstract：:Outbreaks of avian influenza virus continue to pose threats to human health. Animal models such as the mouse, ferret, and macaque are used to understand the pathogenesis of avian influenza virus infection in humans. We previously reported that the tree shrew (Tupaia belangeri, family Tupaiidae), which is regarded as a...

journal_title：Emerging microbes & infections

authors： Li R,Yuan B,Xia X,Zhang S,Du Q,Yang C,Li N,Zhao J,Zhang Y,Zhang R,Feng Y,Jiao J,Peiris M,Zhong N,Mok CKP,Yang Z

更新日期：2018-10-10 00:00:00

abstract：:Coxsackievirus A16 (CA16) is a member of the Picornaviridae family and causes mild and self-limiting hand, foot, and mouth disease (HFMD) in infants and young children. CA16 infection can also progress to central nervous system (CNS) complications; however, the underlying mechanism by which CA16 penetrates the blood-b...

journal_title：Emerging microbes & infections

authors： Song J,Hu Y,Li H,Huang X,Zheng H,Hu Y,Wang J,Jiang X,Li J,Yang Z,Fan H,Guo L,Shi H,He Z,Yang F,Wang X,Dong S,Li Q,Liu L

更新日期：2018-09-19 00:00:00

abstract：:H7N9 influenza viruses emerged in 2013 and have caused severe disease and deaths in humans in China. Some H7N9 viruses circulating in chickens have mutated to highly pathogenic viruses that have caused several disease outbreaks in chickens. Studies have shown that when the H7N9 highly pathogenic viruses replicate in f...

journal_title：Emerging microbes & infections

authors： Yang W,Yin X,Guan L,Li M,Ma S,Shi J,Deng G,Suzuki Y,Chen H

更新日期：2018-09-12 00:00:00

abstract：:Hepatitis C virus (HCV) infection is a major cause of chronic hepatitis and liver cancer worldwide. Adaptive mutations play important roles in the development of the HCV replicon and its infectious clones. We and others have previously identified the p7 mutation F772S and the co-presence of NS4A mutations in infectiou...

journal_title：Emerging microbes & infections

authors： Duan X,Anwar MI,Xu Z,Ma L,Yuan G,Chen Y,Liu X,Xia J,Zhou Y,Li YP

更新日期：2018-08-08 00:00:00

abstract：:Although a number of standardized human immunodeficiency virus 1 (HIV-1) pseudoviruses have been generated to assess neutralizing antibodies, subtype B/B' has not been comprehensively characterized either genotypically or phenotypically. Full-length env genes were isolated from plasma samples derived from B/B'-infecte...

journal_title：Emerging microbes & infections

authors： Xie H,Nie J,Chen Q,Huang W,Wang Y

更新日期：2018-05-16 00:00:00

abstract：:Human enteroviruses frequently cause severe diseases in children. Human enteroviruses are transmitted via the fecal-oral route and respiratory droplets, and primary replication occurs in the gastro-intestinal and respiratory tracts; however, how enteroviruses infect these sites is largely unknown. Human intestinal org...

journal_title：Emerging microbes & infections

authors： van der Sanden SMG,Sachs N,Koekkoek SM,Koen G,Pajkrt D,Clevers H,Wolthers KC

更新日期：2018-05-09 00:00:00

abstract：:Tick-borne encephalitis virus (TBEV) has been classified into three subtypes, namely the European (Eu-TBEV), Far Eastern (FE-TBEV), and Siberian (Sib-TBEV). In this study, we discovered a new subtype of TBEV in wild rodent Marmota himalayana in Qinghai-Tibet Plateau in China, proposed as subtype Himalayan (Him-TBEV). ...

journal_title：Emerging microbes & infections

authors： Dai X,Shang G,Lu S,Yang J,Xu J

更新日期：2018-04-25 00:00:00

abstract：:Acinetobacter baumannii is a notorious pathogen that has emerged as a healthcare nightmare in recent years because it causes serious infections that are associated with high morbidity and mortality rates. Due to its exceptional ability to acquire resistance to almost all available antibiotics, A. baumannii is currentl...

journal_title：Emerging microbes & infections

authors： Elhosseiny NM,Attia AS

更新日期：2018-03-21 00:00:00

abstract：:Whooping cough, caused by Bordetella pertussis, has resurged and presents a global health burden worldwide. B. pertussis strains unable to produce the acellular pertussis vaccine component pertactin (Prn), have been emerging and in some countries represent up to 95% of recent clinical isolates. Knowledge on the effect...

journal_title：Emerging microbes & infections

authors： Hovingh ES,Mariman R,Solans L,Hijdra D,Hamstra HJ,Jongerius I,van Gent M,Mooi F,Locht C,Pinelli E

更新日期：2018-03-21 00:00:00

abstract：:Influenza has been a long-running health problem and novel antiviral drugs are urgently needed. In pre-clinical studies, we demonstrated broad antiviral activity of D, L-lysine-acetylsalicylate glycine (LASAG) against influenza virus (IV) in cell culture and protection against lethal challenge in mice. LASAG is a comp...

journal_title：Emerging microbes & infections

authors： Scheuch G,Canisius S,Nocker K,Hofmann T,Naumann R,Pleschka S,Ludwig S,Welte T,Planz O

更新日期：2018-03-07 00:00:00

abstract：:Recent canine influenza outbreaks have raised concerns about the generation of pathogenic variants that may pose a threat to public health. Here, we examine avian-like H3N2 canine influenza viruses (CIVs) isolated from 2009 to 2013 in South Korea from dogs. Phylogenetic analysis revealed that these viruses are closely...

journal_title：Emerging microbes & infections

authors： Lee IW,Kim YI,Lim GJ,Kwon HI,Si YJ,Park SJ,Kim EH,Kim SM,Nguyen HD,Song MS,Choi YK

更新日期：2018-03-07 00:00:00

abstract：:West Nile virus (WNV) is an arthropod-borne flavivirus of high medical and veterinary importance. The main vectors for WNV are mosquito species of the Culex genus that transmit WNV among birds, and occasionally to humans and horses, which are 'dead-end' hosts. Recently, several studies have been published that aimed t...

journal_title：Emerging microbes & infections

authors： Vogels CB,Göertz GP,Pijlman GP,Koenraadt CJ

更新日期：2017-11-08 00:00:00

abstract：:Pyrazinamide (PZA) is a key antibiotic in current anti-tuberculosis regimens. Although the WHO has stressed the urgent need to obtain data on PZA resistance, in high tuberculosis burden countries, little is known about the level of PZA resistance, the genetic basis of such resistance or its link with Mycobacterium tub...

journal_title：Emerging microbes & infections

authors： Huy NQ,Lucie C,Hoa TTT,Hung NV,Lan NTN,Son NT,Nhung NV,Anh DD,Anne-Laure B,Van Anh NT

更新日期：2017-10-11 00:00:00

abstract：:Highly pathogenic avian influenza H5N1 viruses were first isolated in Bangladesh in February 2007. Subsequently, clades 2.2.2, 2.3.4.2 and 2.3.2.1a were identified in Bangladesh, and our previous surveillance data revealed that by the end of 2014, the circulating viruses exclusively comprised clade 2.3.2.1a. We recent...

journal_title：Emerging microbes & infections

authors： Barman S,Marinova-Petkova A,Hasan MK,Akhtar S,El-Shesheny R,Turner JC,Franks J,Walker D,Seiler J,Friedman K,Kercher L,Jeevan T,Darnell D,Kayali G,Jones-Engel L,McKenzie P,Krauss S,Webby RJ,Webster RG,Feeroz MM

更新日期：2017-08-09 00:00:00

abstract：:MERS-CoV infection emerged in the Kingdom of Saudi Arabia (KSA) in 2012 and has spread to 26 countries. However, 80% of all cases have occurred in KSA. The largest outbreak outside KSA occurred in South Korea (SK) in 2015. In this report, we describe an epidemiological comparison of the two outbreaks. Data from 1299 c...

journal_title：Emerging microbes & infections

authors： Chen X,Chughtai AA,Dyda A,MacIntyre CR

更新日期：2017-06-07 00:00:00

abstract：:Acute meningoencephalitis (AME) is associated with considerable morbidity and mortality in children in developing countries. Clinical specimens were collected from children presenting with AME at two Cambodian paediatric hospitals to determine the major aetiologies associated with AME in the country. Cerebrospinal flu...

journal_title：Emerging microbes & infections

authors： Horwood PF,Duong V,Laurent D,Mey C,Sothy H,Santy K,Richner B,Heng S,Hem S,Cheval J,Gorman C,Dussart P,de Jong MD,Kerleguer A,Guillard B,Murgue B,Lecuit M,de Lamballerie X,Farrar JJ,Tarantola A,Eloit M,Buchy P

更新日期：2017-05-24 00:00:00

abstract：:Human enterovirus 68 (EV-D68) is a rarely reported virus that has been linked to respiratory disease. In recent years, reports about EV-D68 infection have markedly increased worldwide. However, the epidemiological features of this emerging infection are not well understood. To evaluate the emerging EV-D68 epidemic, we...

journal_title：Emerging microbes & infections

authors： Xiang Z,Li L,Ren L,Guo L,Xie Z,Liu C,Li T,Luo M,Paranhos-Baccalà G,Xu W,Wang J

更新日期：2017-05-10 00:00:00

abstract：:From September 2015 to March 2016, hepatitis A notifications in Germany increased by 45% to 699 cases compared to 482 cases in the same period of the previous year. Children aged five to nine years were predominantly affected (22% of all cases in this period). We hypothesized that this increase could be explained by t...

journal_title：Emerging microbes & infections

authors： Michaelis K,Wenzel JJ,Stark K,Faber M

更新日期：2017-04-26 00:00:00

abstract：:The progressive anthropization of caves for food resources or economic purposes increases human exposure to pathogens that naturally infect cave-dwelling animals. The presence of wild or domestic animals in the immediate surroundings of caves also may contribute to increasing the risk of emergence of such pathogens. S...

journal_title：Emerging microbes & infections

authors： Obame-Nkoghe J,Leroy EM,Paupy C

更新日期：2017-04-12 00:00:00

abstract：:Human coronavirus OC43 (HCoV-OC43) is commonly associated with respiratory tract infections in humans, with five genetically distinct genotypes (A to E) described so far. In this study, we obtained the full-length genomes of HCoV-OC43 strains from two previously unrecognized lineages identified among patients presenti...

journal_title：Emerging microbes & infections

authors： Oong XY,Ng KT,Takebe Y,Ng LJ,Chan KG,Chook JB,Kamarulzaman A,Tee KK

更新日期：2017-01-04 00:00:00

abstract：:The first imported case of Middle East respiratory syndrome (MERS) in China recently occurred, allowing for the characterization of antibody titers in a series of the patient's sera using the following methods based on recombinant viral structural antigens: inactivated MERS coronavirus (MERS-CoV) enzyme-linked immunos...

journal_title：Emerging microbes & infections

authors： Wang W,Wang H,Deng Y,Song T,Lan J,Wu G,Ke C,Tan W

更新日期：2016-11-09 00:00:00

abstract：:Zika virus (ZIKV) has become a threat to global health since the outbreak in Brazil in 2015. Although ZIKV is generally considered an Aedes-transmitted pathogen, new evidence has shown that parts of the virus closely resemble Culex-transmitted viruses. Therefore, it is important to evaluate the competence of Culex spe...

journal_title：Emerging microbes & infections

authors： Guo XX,Li CX,Deng YQ,Xing D,Liu QM,Wu Q,Sun AJ,Dong YD,Cao WC,Qin CF,Zhao TY

更新日期：2016-09-07 00:00:00

abstract：:Monoclonal antibodies (mAbs), which currently constitute the main class of biotherapeutics, are now recognized as major medical tools that are increasingly being considered to fight severe viral infections. Indeed, the number of antiviral mAbs developed in recent years has grown exponentially. Although their direct ef...

journal_title：Emerging microbes & infections

authors： Lambour J,Naranjo-Gomez M,Piechaczyk M,Pelegrin M

更新日期：2016-08-17 00:00:00

abstract：:After three decades of intensive research efforts, an effective vaccine against HIV-1 remains to be developed. Several broadly neutralizing antibodies to HIV-1, such as 10E8, recognize the membrane proximal external region (MPER) of the HIV-1 gp41 protein. Thus, the MPER is considered to be a very important target for...

journal_title：Emerging microbes & infections

authors： Sun Z,Zhu Y,Wang Q,Ye L,Dai Y,Su S,Yu F,Ying T,Yang C,Jiang S,Lu L

更新日期：2016-06-22 00:00:00

abstract：:Clostridium difficile is the major causative agent of nosocomial antibiotic-associated diarrhea. In a 2009 outbreak of C. difficile-associated diarrhea that was recorded in a major Costa Rican hospital, the hypervirulent NAP1 strain (45%) predominated together with a local genotype variant (NAPCR1, 31%). Both strains ...

journal_title：Emerging microbes & infections

authors： López-Ureña D,Quesada-Gómez C,Montoya-Ramírez M,del Mar Gamboa-Coronado M,Somogyi T,Rodríguez C,Rodríguez-Cavallini E

更新日期：2016-05-11 00:00:00

abstract：:GRP78/BiP is an endoplasmic reticulum (ER) chaperone protein with the important function of maintaining ER homeostasis, and the overexpression of GRP78/BiP alleviates ER stress. Our previous studies showed that infection with enterovirus 71 (EV71), a (+)RNA picornavirus, induced GRP78/BiP upregulation; however, ectopi...

journal_title：Emerging microbes & infections

authors： Jheng JR,Wang SC,Jheng CR,Horng JT

更新日期：2016-03-23 00:00:00

abstract：:Avian influenza A(H7N9) virus (A(H7N9)) emerged in February 2013. Liver impairment of unknown cause is present in 29% of patients with A(H7N9) infection, some of whom experience severe liver injury. Hypoxic hepatitis (HH) is a type of acute severe liver injury characterized by an abrupt, massive increase in serum amin...

journal_title：Emerging microbes & infections

authors： Zhang Y,Liu J,Yu L,Zhou N,Ding W,Zheng S,Shi D,Li L

更新日期：2016-01-06 00:00:00

abstract：:Norovirus (NoV) is now recognized as a leading cause of nonbacterial acute gastroenteritis; however, the NoV GII.17 genotype has rarely been reported as the predominant genotype in clinical diarrhea cases. During the winter of 2014–2015, the GII.17 genotype, together with the NoV GII.4 genotype, dominated in sporadic ...

journal_title：Emerging microbes & infections

authors： Chen H,Qian F,Xu J,Chan M,Shen Z,Zai S,Shan M,Cai J,Zhang W,He J,Liu Y,Zhang J,Yuan Z,Zhu Z,Hu Y

更新日期：2015-11-01 00:00:00

abstract：:We report the discovery and confirmation of 23 novel mutations with previously undocumented role in isoniazid (INH) drug resistance, in catalase-peroxidase (katG) gene of Mycobacterium tuberculosis (Mtb) isolates. With these mutations, a synonymous mutation in fabG1 (g609a), and two canonical mutations, we were able t...

journal_title：Emerging microbes & infections

authors： Torres JN,Paul LV,Rodwell TC,Victor TC,Amallraja AM,Elghraoui A,Goodmanson AP,Ramirez-Busby SM,Chawla A,Zadorozhny V,Streicher EM,Sirgel FA,Catanzaro D,Rodrigues C,Gler MT,Crudu V,Catanzaro A,Valafar F

更新日期：2015-07-01 00:00:00

abstract：:In March 2013, a patient infected with a novel avian influenza A H7N9 virus was reported in China. Since then, there have been 458 confirmed infection cases and 177 deaths. The virus contains several human-adapted markers, indicating that H7N9 has pandemic potential. The outbreak of this new influenza virus highlighte...

journal_title：Emerging microbes & infections

authors： Leung HC,Chan CC,Poon VK,Zhao HJ,Cheung CY,Ng F,Huang JD,Zheng BJ

更新日期：2015-04-01 00:00:00

abstract：:Babesiosis is a tick-borne, zoonotic disease caused by Babesia spp. Two cases of babesiosis were detected by nested polymerase chain reaction (PCR) in Yunnan province, China, and further confirmed by molecular assay. The blood smears showed intraerythrocytic ring form and tetrads typical of small B. microti. In both c...

journal_title：Emerging microbes & infections

authors： Zhou X,Li SG,Wang JZ,Huang JL,Zhou HJ,Chen JH,Zhou XN

更新日期：2014-08-01 00:00:00

abstract：:Saffold virus (SAFV), a newly discovered human cardiovirus of the Picornaviridae family, causes widespread infection among children, as shown by previous seroprevalence studies. To determine the host cell range of SAFV and its cytopathogenicity, eight mammalian cell lines that were available in the laboratory were scr...

journal_title：Emerging microbes & infections

authors： Xu Y,Victorio CB,Ng Q,Tan YJ,Chua KB

更新日期：2014-02-01 00:00:00

abstract：:Unlike those infected by H5N1, birds infected by the newly discovered H7N9 virus have no observable clinical symptoms. Public health workers in China do not know where the public health threat lies. In this study, we used a distributed focused crawler to analyze online knowledge of the live bird trade in first-wave pr...

journal_title：Emerging microbes & infections

authors： Chen C,Lu S,Du P,Wang H,Yu W,Song H,Xu J

更新日期：2013-12-01 00:00:00

abstract：:Although not previously known to cause human infections, Kocuria species have now emerged as human pathogens, mostly in compromised hosts with severe underlying disease. Recently, there has been an increasing incidence of different types of Kocuria infections reported, most likely due to the adoption of better identif...

journal_title：Emerging microbes & infections

authors： Purty S,Saranathan R,Prashanth K,Narayanan K,Asir J,Sheela Devi C,Kumar Amarnath S

更新日期：2013-10-01 00:00:00

abstract：:Interleukin 17 (IL-17) and its closest relative, IL-17F, have recently drawn much attention in the field of immunology. IL-17 and IL-17F are expressed by a distinct type of T cells, T helper 17 cells and certain other lymphocytes. These cytokines play key regulatory roles in host defense and inflammatory diseases. In ...

journal_title：Emerging microbes & infections

authors： Jin W,Dong C

更新日期：2013-09-01 00:00:00